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KMID : 1134820070360020163
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 2 p.163 ~ p.173
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The Effects of Vitamin C on Lipid Contents and Fatty Acid Compositions of Serum and Liver in Rats Treated with Radiation or Aflatoxin B₁
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Kang Jin-Soon
Kim So-Young
Kim Hee-Suk
Cho Heung-Lae
Chai Gyu-Young
Chung Duck-Hwa
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Abstract
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Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity and carcinogenesis of many carcinogens. This study was carried out to determine the effects of vitamin C on lipid contents and fatty acid compositions of serum and liver in male rats treated with radiation or aflatoxin B₁ (AFB₁). Six week-old male Sprague-Dawley rats were randomly divided into 7 groups; control group, radiation exposed group, AFB₁ treated group, X-ray and AFB₁ co-treated group. Three groups, except control group, were each further divided into vitamin C administered group and not-administered groups. For this study, vitamin C was injected with 10 ㎎/㎏ of body weight by intraperitoneal injection and 1 hr later, 0.4 ㎎/㎏ of AFB₁ was injected by the same method. These administrations were repeated every 3 days over a period of 15 days. Only one time, X-ray was irradiated on whole-liver with 1,500 cGy. Then vitamin C and AFB₁ were administered by the same level and same method described above. On the 16th day of treatments, the animals were sacrificed. From the analysis of the serum lipid patterns, significant decrease (p＜0.01) in triglyceride (TG) and total cholesterol levels were observed in X-ray and AFB₁ co-treated group administered with vitamin C (group 7). In liver lipids, the levels of free cholesterol and total cholesterol were also decreased in X-ray and AFB₁ co-treated group administered with vitamin C (group 7). The levels of serum free cholesterol and hepatic TG were not significantly different among all groups according to vitamin C administrations. The high density lipoprotein (HDL)-cholesterol level of serum was significantly (p＜0.01) increased while the low density lipoprotein (LDL)-cholesterol level was decreased in X-ray and AFB₁ co-treated group administered with vitamin C (group 7). In the phospholipid fatty-acid compositions of serum and liver tissue, group 3, 5 and 7 showed an increase in polyunsaturated fatty acid (PUFA) but a decrease in saturated fatty acid (SFA) when compared to the control group. The composition ratio of fatty acid varied according to vitamin C administration. These results suggested that vitamin C has partly suppressive effects on lipid contents and fatty acid composition of serum and liver in rats treated by radiation and AFB₁.
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KEYWORD
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lipid peroxidation, vitamin C, fatty acid composition, aflatoxin B₁, radiation
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